Nonrandom induction of pyrimidine-pyrimidone (6-4) photoproducts in ultraviolet-irradiated human chromatin.

نویسندگان

  • D L Mitchell
  • T D Nguyen
  • J E Cleaver
چکیده

Radioimmunoassays that detect pyrimidine-pyrimidone (6-4) photoproducts and cyclobutane dimers were used to determine the relative induction of these photoproducts in nucleosomal (core) and internucleosomal (linker) DNA in human cell chromatin irradiated with UV light. Cyclobutane dimers were formed in equal amounts/nucleotide in core and linker DNA, whereas (6-4) photoproducts occurred with 6-fold greater frequency/nucleotide in linker DNA.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 265 10  شماره 

صفحات  -

تاریخ انتشار 1990